Methadone is contraindicated hinein patients with a known hypersensitivity to methadone hydrochloride or any other ingredient rein methadone hydrochloride tablets.
Addiction and misuse warning: Methadone comes with a risk of addiction even when it’s used the right way. This can lead to drug misuse. Having an addiction to and misusing this drug can increase your risk of overdose and death.
Clinical Pharmacology for Pregnancy – Pregnant women appear to have significantly lower trough plasma methadone concentrations, increased plasma methadone clearance, and shorter methadone half-life than after delivery.
Methadone-maintained patients beginning treatment with these antiretroviral drugs should be monitored for evidence of withdrawal effects and methadone dose should Beryllium adjusted accordingly.
Acute Pain – Maintenance patients on a stable dose of methadone Weltgesundheitsorganisation experience physical trauma, postoperative pain or other acute pain cannot Beryllium expected to derive analgesia from their existing dose of methadone. Such patients should Beryllium administered analgesics, including opioids, in doses that would otherwise Beryllium indicated for non-methadone-treated patients with similar painful conditions.
Methadone treatment for analgesic therapy in patients with acute or chronic pain should only Beryllium initiated if the potential analgesic or palliative care benefit of treatment with methadone has been considered to outweigh the risk of QT prolongation that has been reported with high doses of methadone.
Abnormal fetal nonstress tests (NSTs) have been reported to occur more frequently when the test is performed 1 to 2 hours after a maintenance dose of methadone rein late pregnancy compared to controls.
Patients should be cautioned that alcohol and other CNS depressants may produce an additive CNS depression when taken with this product and should be avoided.
Methadone is contraindicated hinein any situation where opioids are contraindicated such as: patients with respiratory depression (in the absence of resuscitative equipment or hinein unmonitored settings), and in patients with acute bronchial asthma or hypercarbia.
Tolerance is the need for increasing doses of opioids to maintain a defined effect such Methadontabletten zur Schmerzbehandlung as analgesia (in the absence of disease progression or other external factors).
for maintenance treatment of narcotic drug addiction along with other social and medical services. Stopping maintenance treatment of narcotic drug addiction with methadone hydrochloride tablets may result in a return to narcotic drug use.
Physicians should individualize treatment rein every case (Weiher DOSAGE AND ADMINISTRATION), taking into account the high degree of interpatient variability hinein response to and metabolism of methadone.
“Drug-seeking” behavior is very common in addicts and drug abusers. Drug-seeking tactics include emergency calls or visits near the end of office hours, refusal to undergo appropriate examination, testing or referral, repeated claims of lost prescriptions, tampering with prescriptions and reluctance to provide prior medical records or contact information for other treating physician(s).
There is considerable variability rein the appropriate rate of methadone taper rein patients choosing medically supervised withdrawal from methadone treatment. It is generally suggested that dose reductions should Beryllium less than 10% of the established tolerance or maintenance dose, and that 10 to 14-day intervals should elapse between dose reductions.